I am currently a PhD candidate at the School of Medicine in the Chinese University of Hong Kong, Shenzhen (CUHKSZ). I holds a Bachelor's Degree in the School of Life Science from Sun Yat-sen University (SYSU). My research interests cover Bioinformatics, Biological Big Data Platforms, and Artificial Intelligence for Drug Development (AIDD).

I am primarily focused on the development of DrugRepoSuite, a platform for drug repositioning, which enables the discovery of drug targets, new indications for drugs, side effects of co-administered drugs, and miRNA regulation of drugs. The platform includes a series of databases and algorithms:

1. CapBM-DTI (Drug-target interaction prediction tool) (IJMS, 2023)

2. DrugRepoBank (Drug repositioning platform) (Database, 2024)

3. DDI-ESPredictor (Side effect type and severity prediction tool for combination drugs)

4. DeepDrugmiR (Key miRNA prediction tool for drugs) (ACM-BCB 2024, Oral, Accept Rate=36/204)

5. miRTarBase (A database for miRNA-target interaction) (NAR, 2023)

6. MethHC (A database for human cancer methylation) (NAR, 2022)

We are also exploring the treatment of sorafenib-resistant hepatocellular carcinoma using the developed platform and conducting experimental validation (in collaboration with biologists).

To date, I have published 17 peer-reviewed papers (5 papers as first or co-first author, 2 with IF > 10, 1 ESI Highly Cited Paper) in top journals such as Nucleic Acids Research (IF=14.9), Database (IF=5.8), Briefings in Bioinformatics (IF=9.5), and Protein Science (IF=8.0). These papers have collectively garnered over 600 citations.

For an extensive list of my publications, please consult both my Google Scholar and ORCID profiles.




1. Yixian Huang#, Huacong Wu#, Ying Cai, Danhong Dong, Sicong Yu, Yigang Chen, Zihao Zhu, Yang-Chi-Dung Lin, Hsi-Yuan Huang^*, Hsien-Da Huang^*. DeepDrugmiR: a two-stage deep learning method for inferring small molecules’ regulatory effects on microRNA expression. ACM-BCB 2024
   Oral, Accept Rate=36/204
   
   Website:https://awi.cuhk.edu.cn/~DeepDrugmiR URL:https://dl.acm.org/doi/10.1145/3698587.3701351
   (首个双阶段的基于化学和DNA语言模型的药物作用miRNA调控预测工具)
   

2. Yixian Huang, Danhong Dong, Wenyang Zhang, Ruiting Wang, Yang-Chi-Dung Lin, Huali Zuo, Hsi-Yuan Huang^*, Hsien-Da Huang^*. DrugRepoBank: a comprehensive database and discovery platform for accelerating drug repositioning. Database, Volume 2024, 2024, baae051,
   (First Authorship,IF(2023)=5.8)
   
   Website:https://awi.cuhk.edu.cn/DrugRepoBank URL:https://doi.org/10.1093/database/baae051
   (一个综合性的药物开发平台以加速老药新用进程；荣获中国科学网报导；生物信息学著名微信公众号AdvanceBC报导)
   

3. Yixian Huang#, Hsi-Yuan Huang#, Yigang Chen, Yang-Chi-Dung Lin, Lantian Yao, Tianxiu Lin, Junlin Leng, Yuan Chang, Yuntian Zhang, Zihao Zhu, Kun Ma, Yeong-Nan Cheng, Tzong-Yi Lee, Hsien-Da Huang^*. A Robust Drug-Target Interaction Prediction Framework with Capsule Network and Transfer Learning. International Journal of Molecualr Science, 2023, 24(18), 14061.
   (First Authorship,IF(2023)=5.6)
   
   URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531393/
   (基于胶囊网络和迁移学习的药物靶标预测工具)
   

4. Hsi-Yuan Huang#, Yang-Chi-Dung Lin#, Shidong Cui#, Yixian Huang#, Yun Tang, Jiatong Xu, Jiayang Bao, Yulin Li, Jia Wen, Huali Zuo, Weijuan Wang, Jin Li, Jie Ni, Yini Ruan, Liping Li, Yidan Chen, Yueyang Xie, Zihao Zhu, Xiaoxuan Cai, Xinyi Chen, Lantian Yao, Yigang Chen, Yijun Luo, Shupeng LuXu, Mengqi Luo, Chih-Min Chiu, Kun Ma, Lizhe Zhu, Gui-Juan Cheng, Chen Bai, Ying-Chih Chiang, Liping Wang, Fengxiang Wei^*, Tzong-Yi Lee^*, Hsien-Da Huang^*. miRTarBase update 2022: an informative resource for experimentally validated miRNA–target interactions. Nucleic Acids Research, Volume 50, Issue D1, 7 January 2022, Pages D222–D230.
   (Co-first Authorship, IF(2023)=14.9)
   
   Website:https://mirtarbase.cuhk.edu.cn/~miRTarBase/miRTarBase_2022 URL:https://doi.org/10.1093/nar/gkab1079
   (实验验证的miRNA靶标综合性数据库；ESI高被引论文；系列论文获2020年度中国生物信息学十大进展)
   

5. Hsi-Yuan Huang#, Jing Li#, Yun Tang#, Yi-Xian Huang#, Yi-Gang Chen, Yue-Yang Xie, Zhe-Yuan Zhou, Xin-Yi Chen, Si-Yuan Ding, Meng-Fan Luo, Chen-Nan Jin, Le-Shan Zhao, Jia-Tong Xu, Ying Zhou, Yang-Chi-Dung Lin, Hsiao-Chin Hong, Hua-Li Zuo, Si-Yao Hu, Pei-Yi Xu, Xin Li, Hsien-Da Huang^*. MethHC 2.0: information repository of DNA methylation and gene expression in human cancer. Nucleic Acids Research, Volume 49, Issue D1, 8 January 2021, Pages D1268–D1275.
   (Co-first Authorship, IF(2023)=14.9)
   
   Website:https://awi.cuhk.edu.cn/~MethHC/methhc_2020 URL:https://doi.org/10.1093/nar/gkaa1104
   (人类癌症DNA甲基化综合性数据库)
   

1. Ganghong Annual Research Award for PhD Students, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2024

2. Ganghong Scholarship, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2020-2025

3. Outstanding Undergraduate Graduates, School of Life Science, Sun Yat-sen University, 2019

4. Academic Innovation Award, School of Life Science, Sun Yat-sen University, 2019

5. National Encouragement Scholarship, School of Life Science, Sun Yat-sen University, 2016-2018

1. Bioinformatics, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Teaching Assistant, 09/2020-05/2023

2. Computational Genomics and Proteomics, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Teaching Assistant, 09/2020-05/2023

3. Statistical Methods for Biomedical Research, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Teaching Assistant, 09/2023-01/2024

4. Machine Learning for Biomedical Research, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Teaching Assistant, 09/2023-01/2024

• Yixian Huang at yixianhuang@link.cuhk.edu.cn
• The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen, Guangdong Province, China